CNT2 inhibitor-1 ( —— )

产品货号. M26125 CAS No. 880155-70-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CNT2 inhibitor-1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CNT2抑制剂-1是集中核苷转运蛋白2（CNT2；hCNT2的IC50：640 nM）的有效抑制剂。
产品描述

CNT2 inhibitor-1 is a potent inhibitor of concentrative nucleoside transporter 2 (CNT2; IC50: 640 nM for hCNT2).(In Vitro):CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors.
体外实验

CNT2 inhibitor-1 (compound 48) exhibits 81-fold more potent inhibitory activity than the parent compound 12. In addition, CNT2 inhibitor-1 exhibits inhibitory activity 1500-fold more potent than that of 2’-deoxy-5-fluorouridine, phlorizin, and 7,8,3’-trihydroxyflavone, which are well-known hCNT2 inhibitors. CNT2 inhibitor-1 (compound 1) is a potent inhibitor with poor solubility.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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CAS Number

880155-70-4
分子量

448.483
分子式

C23H24N6O4
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 75 mg/mL (167.24 mM)
SMILES

Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCc3ccc(cc3)-c3ccccc3)nc12
化学全称

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计算器

产品手册

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